If you’ve read Progesterone: A Love Story, you might be wondering if supplemental progesterone could help ease your perimenopause or menopause symptoms. Here’s your go-to guide for getting up to speed on progesterone so that you can have the information you need when you talk to your healthcare provider.
Natural vs. Synthetic: What’s the Difference?
Progesterone in hormone therapy typically comes in two forms: natural progesterone (usually derived from wild yams) and synthetic progestins (lab-made). Natural progesterone is bioidentical—it matches the structure of what your body makes. Synthetic progestins, while similar, aren’t an exact match.bSome studies suggest natural progesterone may come with fewer risks and side effects.
How to Take It
There are a few common ways to supplement with progesterone:
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Pills – Familiar and easy to take, but slower to absorb.
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Creams & Gels – Applied to skin, though absorption isn’t always reliable.
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Vaginal Suppositories – Targeted and effective (we’re big fans!).
What’s best depends on your symptoms, lifestyle, and your healthcare provider’s advice.
Potential Side Effects
Just like skincare or supplements, progesterone isn’t a one-size-fits-all solution. Some people experience:
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Bloating
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Breast tenderness
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Mood swings
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Headaches
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Nausea
If something feels off, trust your body and talk to your provider.
Blood Clot Risk: What You Should Know
Some studies suggest progesterone *may* increase blood clot risk, especially if other factors are present—like smoking, obesity, or a personal history of clots. But here’s the nuance: much of that risk appears to be linked to *synthetic* progestins, not natural forms.
According to this study in BMJ, micronized progesterone doesn’t affect clotting factors when combined with transdermal estrogen. A recent meta-analysis even showed no increase in VTE risk among women using transdermal estrogen and oral, micronized progesterone.
Bottom line: work with your doctor to assess your personal risk before starting any hormone therapy.
Regular Check-Ins Are Key
If you choose to start progesterone therapy, regular follow-ups matter. Monitoring hormone levels, symptoms, and side effects keeps you in control of your health. Knowledge is power—especially when it comes to your hormones. Whether you’re researching or ready to dive in, being informed helps you advocate for your body.
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